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Alan Johnson has everything he needs to get through life: a good job, a beautiful and loving wife, and their wonderful children. Yet he feels isolated because he finds having a hard-working job and managing a family too much to handle and has no one to talk to about it. Charlie Fineman, on the other hand, doesn’t have a job or a family. He used to have both until he lost his family on the fateful day of 9/11, and the grief he felt caused him to quit his job and isolate himself from everyone around him. As it turns out, Alan and Charlie were roommates in college, and a chance encounter one night rekindles the friendship they shared. They soon feel that their friendship is the one thing that allows them to forget about their problems.

A middle-aged crime boss (Malcolm McDowell) smugly reflects back from 1999, narrating the brutality which made him triumphant - and feared. As an unnamed young hood (played by Paul Bettany) in Swinging 60’s London, he seemed to ape his mod boss Freddie Mays (David Thewlis), and do anything for him. But his narration exposes all-consuming envy: of Freddie’s supremacy, and especially his tall bird (Saffron Burrows). The baby shark develops his viciousness and backstabbing, scheming to be Gangster No. 1.

Samual L Jackson plays a businessman who sinks $200 million into a special project to help fight brain cancer. As part of this project, medical biologist Susan McAlester (Saffron Burrows) rather naughtily figures out a way to genetically embiggen shark brains, so that cancer-battling enzymes can be harvested. However, the shark subjects become super smart and decide they don’t much like being cooped up in pens and being stabbed with hypodermics, so they figure a way to break out and make for the open sea…